[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fgyIE2h1M_EN3T0Wc8K0VkPeO8dKUaon2b820YNVjbW0":3},{"answer":4,"createTime":5,"id":6,"options":7,"origin":13,"question":20,"related":21,"source":32,"type":33},[],"2023-11-03 11:05:16",102847113,[8,9,10,11,12],"Protein production","Two new daughter strands","Heavy DNA","Induced mutations","mRNA transcripts",{"count":14,"courseId":15,"courseImg":16,"courseName":17,"workId":18,"workName":19},10,"26dbb0831282ce51fb2ab78c687fde14","https:\u002F\u002Ftihai-oss-cloud.itihey.com\u002Fimg\u002F0d27132e8e4c25614916fe2373258c2e.jpg","2023生物化学","38381f0081a14431a334ec90544d9dc6","DNA的生物合成(复制)","DNA replication results in",[22,34,44,54,63,66,76,85,94,103],{"answer":23,"createTime":5,"id":24,"options":25,"question":31,"source":32,"type":33},[],102847107,[26,27,28,29,30],"Eukaryotic DNA polymerases are extraordinarily fast compared with prokaryotic polymerases","The higher temperature of mammalian cells allows for an exponentially higher replication rate","The presence of histones in mammalian chromatin speeds up the rate of DNA replication","Histones and microRNAs complexed with bacterial DNA speed up the rate of DNA replication","Hundreds of replication forks work simultaneously on each piece of mammalian genomic DNA","why mammalian genomes are 100 times the size of bacterial genomes yet are replicated in just a few minutes. Which of the following best explains this fact","v1",0,{"answer":35,"createTime":5,"id":36,"options":37,"question":43,"source":32,"type":33},[],102847108,[38,39,40,41,42],"Unwinding proteins","DNA-directed RNA polymerase","DNA polymerase I","DNA ligase","DNA-directed DNA polymerase","A 2-year-old child presents with poor weight gain, sparse hair, unusual face with sunken eyes, and skin that reddens markedly in sunlight. A diagnosis of Cockayne syndrome (MIM*216400) is considered and studies of DNA synthesis are undertaken. In vitro assay of labeled thymidine incorporation reveals decreased levels of DNA synthesis compared to controls, but normal-sized labeled DNA fragments. The addition of protein extract from normal cells gently heated to inactivate DNA polymerase restores DNA synthesis in Cockayne cells to normal. Which of the following enzymes used in DNA replication is most likely to be defective in Cockayne syndrome",{"answer":45,"createTime":5,"id":46,"options":47,"question":53,"source":32,"type":33},[],102847110,[48,49,50,51,52],"ACGACGACG to ACAAACACG","AGAATAACA to AAAATAACA","AACAACAAC to AACAAGAAC","AAAATGAGC to AAAATAAGC","AGGAATATG to AGGAATATT","Part of the triplet genetic code involving mRNA codon triplets that start with U is shown below. Using the portion of the genetic code shown, which of the following mutations in the 3' to 5' DNA template segments corresponds to a nonsense mutation?\u003Cimg src=\"https:\u002F\u002Ftihai-oss-cloud.itihey.com\u002Fimg\u002Fb16b4875cb76c3cd5a77b41c5dd6ca01.jpg\">",{"answer":55,"createTime":5,"id":56,"options":57,"question":62,"source":32,"type":33},[],102847111,[58,59,60,61],"Hydrolytic cleavage","Helical pairing","Semiconservative replication","Heredity","Replication of DNA starts with the unwinding of the entire DNA molecule. Each original strand is a therefore a template from which a new strand is synthesized based on complementary base pairing by DNA polymerase. The new DNA consists of an old parent strand and a new daughter strand. This process is called",{"answer":64,"createTime":5,"id":6,"options":65,"question":20,"source":32,"type":33},[],[8,9,10,11,12],{"answer":67,"createTime":5,"id":68,"options":69,"question":75,"source":32,"type":33},[],102847117,[70,71,72,73,74],"Requires less energy B、C、 D、","Only one DNA strand can be copied at a time","Increased fidelity","DNA replication starts at specific sites only","RNA primer limitations","DNA replication is semiconservative. Why do you think this is true",{"answer":77,"createTime":5,"id":78,"options":79,"question":84,"source":32,"type":33},[],102847120,[80,81,82,83],"A、There is a shortage of dNTPs for lagging strand synthesis","Okazaki fragments are riddled with mistakes; proofreading enzymes chop up the nucleotide into short fragments","Lagging strand DNA polymerase can only handle a few nucleotides at a time","DNA is synthesized 5' to 3'. Replication can only proceed from the unwound portion of DNA outward","Why does lagging strand synthesis consist of discontinuous Okazaki fragments",{"answer":86,"createTime":5,"id":87,"options":88,"question":93,"source":32,"type":33},[],102847122,[89,90,91,92],"They contain arginine and lysine residues","They hydrolyze phosphodiester bonds","Sequence-specific binding","They form covalent bonds to sugars","Single-stranded binding proteins (SSB) bind to the outer backbone of DNA during replication. What would you predict about SSBs",{"answer":95,"createTime":5,"id":96,"options":97,"question":98,"source":32,"type":33},[],102847123,[98,99,100,101,102],"Telomerase contains a ribozyme","Telomerase adds a repeating sequence to the 5' end of DNA","Telomerase activity decreases as the cell ages","Telomerase adds a repeating sequence to the 3' end of DNA","Telomerase is found only in eukaryotes",{"answer":104,"createTime":5,"id":105,"options":106,"question":111,"source":32,"type":33},[],102847124,[41,107,108,109,110],"DNA gyrase","DNA II","Topoisomerase","DNA Polymerase I and III","DNA replication is not perfect; a mistake is made for every 104 to 105 nucleotides added. However, there are proofreading enzymes that excise incorrect bases and insert the correct one. Which of the following enzymes proofread DNA"]