[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fHY54kIy1qHiHItp-hWdBuIUAL-kOySjRQ5M2Ou0mLO8":3},{"answer":4,"createTime":5,"id":6,"options":7,"origin":13,"question":17,"related":18,"source":29,"type":30},[],"2026-05-08 13:58:16",362524823,[8,9,10,11,12],"Proteolysis during expansion, and resynthesis during contraction","Breaking of disulfide bonds during expansion, and reformation of these bonds during contraction","A decrease in entropy during expansion, and an increase in entropy during contraction","The breaking of salt bridges during expansion, and reformation of the salt bridges during contraction","Hydroxylation of elastin during expansion, and decarboxylation of elastin during contraction",{"courseId":14,"courseImg":15,"courseName":16},"53e1d2ef4961cca8eea3e23969ad2cb9","https:\u002F\u002Ftihai-oss-cloud.itihey.com\u002Fimg\u002F03a579384a6dc297c89809b582fcc767.png","默认课程","The underlying mechanism that allows elastin to exhibit elastic properties (expand and contract) is which one of the following",[19,31,34,44,54,64,74,84,95,104],{"answer":20,"createTime":5,"id":21,"options":22,"question":28,"source":29,"type":30},[],362524822,[23,24,25,26,27],"The formation of disulfide bonds, which initiates tropocollagen formation","The formation of lysyl cross-links between collagen molecules","Transcription of the collagen genes","The formation of collagen fibrils","The hydroxylation of proline residues, which stabilizes the collagen structure","Individuals who develop scurvy suffer from sore and bleeding gums and loss of teeth. This is a result, in part, of the synthesis of a defective collagen molecule. The step that is affected in collagen biosynthesis attributable to scurvy is which one of the following","v1",0,{"answer":32,"createTime":5,"id":6,"options":33,"question":17,"source":29,"type":30},[],[8,9,10,11,12],{"answer":35,"createTime":5,"id":36,"options":37,"question":43,"source":29,"type":30},[],362524824,[38,39,40,41,42],"Charge attraction between GAG chains","Charge repulsion between GAG chains","Hydrogen bonding between GAG chains","Covalent cross-linking between GAG chains","Hydroxylation of adjacent GAG chains","The underlying mechanism by which GAGs allow for the formation of a gel-like substance in the ECM is which one of the following",{"answer":45,"createTime":5,"id":46,"options":47,"question":53,"source":29,"type":30},[],362524825,[48,49,50,51,52],"Collagen","Laminin","Proteoglycans","Elastin","MMPs","The movement of tumor cells from their site of origin to other locations within the body requires the activity of which one of the following proteins",{"answer":55,"createTime":5,"id":56,"options":57,"question":63,"source":29,"type":30},[],362524826,[58,59,60,61,62],"To inhibit the action of MMPs","To coordinate collagen deposition within the ECM","To fix the position of cells within the ECM","To regulate GAG production","To extend GAG chains using nucleotide sugars","Fibronectin is frequently absent in malignant fibroblast cells. One of the major functions of fibronectin is which one of the following",{"answer":65,"createTime":5,"id":66,"options":67,"question":73,"source":29,"type":30},[],362524827,[68,69,70,71,72],"Loss of negative charges on the proteoglycans","Loss of positive charges on the proteoglycans","Gain of negative charges on the proteoglycans","Increased concentration of glucuronic acid residues","Increased concentration of sulfated sugars on the proteoglycans","Which one of the following alterations would reduce the ability of cartilage to cushion weight-bearing activities at joints",{"answer":75,"createTime":5,"id":76,"options":77,"question":83,"source":29,"type":30},[],362524828,[78,79,80,81,82],"Proline to hydroxyproline","Glycine to cysteine","Proline to glycine","Glycine to proline","Serine to proline","A newborn displays the symptoms of a moderate case of OI. Analysis of the child's collagen by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) indicates a molecular species with a greater-than-normal molecular weight. Treatment of the child's collagen with β-mercaptoethanol prior to SDS-PAGE results in a normal-sized collagen. The mutation in this child is most likely which one of the following",{"answer":85,"createTime":5,"id":86,"options":87,"question":94,"source":29,"type":30},[],362524829,[88,89,90,91,92,93],"Stimulation of osteoclast activity","Inhibition of osteoclast activity","Stimulation of osteoblast activity","Inhibition of osteoblast activity","Stimulation of laminin synthesis","Inhibition of laminin synthesis","Bisphosphonate treatment of children with OI is based on which one of the following",{"answer":96,"createTime":5,"id":97,"options":98,"question":103,"source":29,"type":30},[],362524830,[99,100,101,102,51],"Proline","Hydroxyproline","Lysine","Glycine","Collagen provides great tensile strength to connective tissue by its structure as a triple helix. Which amino acid is critical in allowing triple-helix formation",{"answer":105,"createTime":5,"id":106,"options":107,"question":114,"source":29,"type":30},[],362524831,[108,109,110,111,112,113],"A","B","C","D","E","F","A common feature of the mucopolysaccharidoses is the accumulation of heparin sulfate. Which of the following disorders leads to an accumulation of that particular GAG? Choose the one best answer.\u003Cimg src=\"https:\u002F\u002Ftihai-oss-cloud.itihey.com\u002Fimg\u002F9d10570626137aa9438c5e599e2f9be2.png\">"]