A. Protein folding is assisted by intervention of specialized auxiliary proteins called chaperone

B. Protein folding tends to be modular, with areas of local secondary structure forming first, then coalescing into a molten globule

C. Protein folding is driven first and foremost by the thermodynamics of the water molecules surrounding the nascent polypeptide

D. The formation of S-S bond in a mature protein is facilitated by the enzyme protein disulfide isomerase

E. Only a few unusual proteins, such as collagen, require posttranslational processing by partial proteolysis to attain their mature conformation