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单选题 A newborn displays the symptoms of a moderate case of OI. Analysis of the child's collagen by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) indicates a molecular species with a greater-than-normal molecular weight. Treatment of the child's collagen with β-mercaptoethanol prior to SDS-PAGE results in a normal-sized collagen. The mutation in this child is most likely which one of the following
学科：默认课程
时间：2026-05-08 05:58:16
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题目1单选题
Individuals who develop scurvy suffer from sore and bleeding gums and loss of teeth. This is a result, in part, of the synthesis of a defective collagen molecule. The step that is affected in collagen biosynthesis attributable to scurvy is which one of the followingA. The formation of disulfide bonds, which initiates tropocollagen formationB. The formation of lysyl cross-links between collagen moleculesC. Transcription of the collagen genesD. The formation of collagen fibrilsE. The hydroxylation of proline residues, which stabilizes the collagen structure
题目2单选题
The underlying mechanism that allows elastin to exhibit elastic properties (expand and contract) is which one of the followingA. Proteolysis during expansion, and resynthesis during contractionB. Breaking of disulfide bonds during expansion, and reformation of these bonds during contractionC. A decrease in entropy during expansion, and an increase in entropy during contractionD. The breaking of salt bridges during expansion, and reformation of the salt bridges during contractionE. Hydroxylation of elastin during expansion, and decarboxylation of elastin during contraction
题目3单选题
The underlying mechanism by which GAGs allow for the formation of a gel-like substance in the ECM is which one of the followingA. Charge attraction between GAG chainsB. Charge repulsion between GAG chainsC. Hydrogen bonding between GAG chainsD. Covalent cross-linking between GAG chainsE. Hydroxylation of adjacent GAG chains
题目4单选题
The movement of tumor cells from their site of origin to other locations within the body requires the activity of which one of the following proteinsA. CollagenB. LamininC. ProteoglycansD. ElastinE. MMPs
题目5单选题
Fibronectin is frequently absent in malignant fibroblast cells. One of the major functions of fibronectin is which one of the followingA. To inhibit the action of MMPsB. To coordinate collagen deposition within the ECMC. To fix the position of cells within the ECMD. To regulate GAG productionE. To extend GAG chains using nucleotide sugars
题目6单选题
Which one of the following alterations would reduce the ability of cartilage to cushion weight-bearing activities at jointsA. Loss of negative charges on the proteoglycansB. Loss of positive charges on the proteoglycansC. Gain of negative charges on the proteoglycansD. Increased concentration of glucuronic acid residuesE. Increased concentration of sulfated sugars on the proteoglycans
题目7单选题
A newborn displays the symptoms of a moderate case of OI. Analysis of the child's collagen by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) indicates a molecular species with a greater-than-normal molecular weight. Treatment of the child's collagen with β-mercaptoethanol prior to SDS-PAGE results in a normal-sized collagen. The mutation in this child is most likely which one of the followingA. Proline to hydroxyprolineB. Glycine to cysteineC. Proline to glycineD. Glycine to prolineE. Serine to proline
题目8单选题
Bisphosphonate treatment of children with OI is based on which one of the followingA. Stimulation of osteoclast activityB. Inhibition of osteoclast activityC. Stimulation of osteoblast activityD. Inhibition of osteoblast activityE. Stimulation of laminin synthesisF. Inhibition of laminin synthesis
题目9单选题
Collagen provides great tensile strength to connective tissue by its structure as a triple helix. Which amino acid is critical in allowing triple-helix formationA. ProlineB. HydroxyprolineC. LysineD. GlycineE. Elastin
题目10单选题
A common feature of the mucopolysaccharidoses is the accumulation of heparin sulfate. Which of the following disorders leads to an accumulation of that particular GAG? Choose the one best answer.<img src="https://tihai-oss-cloud.itihey.com/img/9d10570626137aa9438c5e599e2f9be2.png">A. AB. BC. CD. DE. EF. F
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